1966, Inc. Presents Leslie
Powered by Conduit Mobile

Leslie's Truth

Leslie McCloud's Latest Articles

Sunday, December 28, 2008

Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements Rather than Mega-Dose Resveratrol Alone

According to the latest science, resveratrol pill users are best advised to consume modest doses of resveratrol plus an array of antioxidant molecules as typically provided in 3 to 5 glasses of aged, red wine, rather than resveratrol alone.

The most recent study shows mega-dose resveratrol alone fails to prolong the life of laboratory mice. In fact, mega-doses shortened the life of animals compared to a standard calorie diet with no resveratrol.
"While resveratrol an antioxidant molecule concentrated in red wine (about 1 milligram per glass), is touted for its health properties, partially explaining the French Paradox (why French wine drinkers have cardiac mortality rates 30% lower than North Americans despite their high-calorie, high-fat diets), it is not the sole molecule responsible for longevity," says Bill Sardi, spokesperson for Longevinex(R), a leading brand of resveratrol dietary supplement.

"The total array of red wine molecules found in the best red wine, about 60 milligrams per 5-ounce glass, or 180-300 milligrams in 3 to 5 glasses, is the suggested healthy dosage range," says Sardi.

Consistently, studies show modest doses of red wine lower mortality rates over abstention or over-consumption. [American Journal Epidemiology 1986 Sep; 124(3):481-9] Red wine pills offer the advantage of no alcohol, no calories or sulfite preservatives.

The negative effect upon lifespan with mega-dose resveratrol may emanate from over-inhibition of tumor necrosis factor (TNF), an inflammatory factor. Excessive TNF leads to inflammation, while too little impairs the immune system, says Sardi.

"We know that over-inhibition of TNF in humans increases the risk for lymphoma (cancer that originates in lymphocytes, a type of white blood cell)," says Sardi.
"When laboratory mice were given mega-dose resveratrol they did not live as long and largely succumbed to lymphoma. Resveratrol is a known TNF inhibitor," adds Sardi.

Newspaperproject.org